All Things Complement

All Things to All People

Myc is an enigma wrapped in a mystery. Attempts to identify Myc target genes, particularly in cancer, have been fraught with dead ends and context-specific functions. Lin et al. and Nie et al. address this conundrum by showing that Myc acts to amplify the output of existing transcriptionally active genes.

' All Things Considered

EHPnet: All Things Toxic

When it is discovered that a toxicant in the environment may pose a threat to human health, a multitude of questions arise. People in the affected community want to know if they could have been exposed to the toxicant, and if so, whether they may get sick from the exposure, and how to avoid any risk the toxicant might pose. Physicians and epi-demiologists need current information on how to diag...

All Things New

Master of all things phosphorylated.

Serine/threonine phosphorylation plays a central role in cellular regulation, either by altering a protein's activity directly or by inducing specific protein-protein interactions, which, in turn, affect localization, binding specificity or activity. One group of molecules that bind to phosphoserine/phosphothreonine-containing sequences are the 14-3-3 proteins, which regulate a wide range of ce...